Neurogastrx Products


for the treatment of gastroparesis

Gastroparesis is a syndrome characterized by delayed gastric emptying in the absence of mechanical obstruction of the stomach. The etiology of gastroparesis may be diverse, but most cases are classified as idiopathic or occurring secondary to diabetes mellitus. Population-based studies have shown that approximately 20% of patients with diabetes have upper GI symptoms. There is currently no adequate treatment for nausea and vomiting associated with gastroparesis and hospitalization is often required for moderate-to-severe cases. The only approved therapy in the US, metoclopramide (Reglan), has significant CNS toxicities resulting in a black box warning limiting use to 12-weeks. Pure pro-kinetic approaches (attempts to increase gastric motility) have not been successful, indicating that nausea and vomiting are important symptoms of gastroparesis not alleviated by pro-kinetic action alone.

NG101 is a potent, selective and peripherally restricted dopamine D2/D3 receptor antagonist. NG101 does not cross the blood-brain-barrier and has not been shown to alter cardiac rhythm which may provide a tolerability advantage compared to existing D2 antagonists.

Neurogastrx is developing NG101 for the treatment of gastroparesis. We have generated preclinical data indicating that in addition to its potent antiemetic properties, NG101 is also expected to significantly increase gastric motility, conferring NG101 an ideal pharmacological profile for the treatment of gastroparesis.