Jim brings more than 10 years of GI experience to Neurogastrx after having been one of the original members of the Linzess team at Ironwood Pharmaceuticals. Jim had both commercial and business development responsibilities at Ironwood and left the company as Senior Vice President of Corporate Development. While at Ironwood he developed the initial Linzess commercial profile and directed transaction strategies, deal sourcing, diligence, and negotiations culminating in deals in the US, Europe, Japan and China. Prior to joining Ironwood Jim was Vice President of Corporate Development for Cozint Interactive, one of the first on-line market intelligence companies. Jim started his biotech career at MPM Capital where he was a Vice President focusing on business development transactions for emerging biotech companies. Jim has a BS in Pharmacy from the Massachusetts College of Pharmacy.
Dr. Cyril De Colle, Founder and Chief Scientific Officer, brings over 20 years of experience as a successful pharmaceutical scientist leading multiple discovery stage programs through IND submission and into clinical trials. Prior to Neurogastrx, Cyril served as Vice President, Neuroscience at Kinemed, where he led the neuroscience division advising multiple global and venture backed pharmaceutical companies on drug development programs. Prior to Kinemed, he managed and led clinical stage programs targeting neurological disorders at Jazz Pharmaceuticals (Nasdaq: JAZZ). Dr. De Colle has also served as a Senior Research Scientist at international pharmaceutical companies including Amgen (Nasdaq: AMGN) and Roche Pharmaceuticals where he successfully led neurodegenerative and neuropsychiatric programs from discovery stage into clinical trials. Dr. De Colle began his pharmaceutical research career at Parke-Davis (Pfizer). He received a MS in Pharmacology and a Ph.D. in Neuroscience from the University of Montpellier in France.
Jeff brings 30 years of clinical development experience in the pharmaceutical and biotechnology industry to his new role at Neurogastrx. As Vice President at Ironwood Pharmaceuticals in Cambridge, MA, he was the architect and leader of linaclotide clinical development from Phase 1 through Phase 3 and NDA submission, review, approval and launch in the US and EU. In addition, he was the Ironwood lead for development with partner companies in Japan (approved) and China (under review). Prior to Ironwood, Dr. Johnston served as Chief Development Officer and Vice President of Drug Development at Critical Therapeutics in Lexington, MA where he led an early phase development program targeting sepsis. He was previously Vice President and Chief Medical Officer at Triangle Pharmaceuticals and spent more than a dozen years in positions of increasing seniority in the clinical development organization at GlaxoSmithKline. He received his BS degree from Davidson College (valedictorian) and MD from Duke University. Prior to joining the pharmaceutical industry Jeff was on the faculty of the University of Utah and the University of Texas at San Antonio Schools of Medicine and, while at GSK he was Clinical Professor of Medicine at the University of North Carolina. He has been elected to fellowship in the American College of Physicians, the American College of Gastroenterology, and the American Gastroenterological Association. His work has been widely published in peer-reviewed journals.